Acute Nicotinic Acid Deficiency

Production of Nicotinic Acid Deficiency with 3- Acetylpyridine, the Ketone Analogue of Nicotinic Acid

Since it has been shown during the past two years that diseases with signs characteristic of specific vitamin deficiencies may be produced by the feeding of certain structural analogues of various vitamins, and that these diseases may be cured by adequate doses of the vitamin concerned (l-4), it has seemed desirable to study the types of structural change which, when applied to a vitamin or oth...

Studies on Nicotinic Acid Deficiency in the Chick*

In a previous report (I) it was demonstrated that chicks receiving purified rations low in nicotinic acid grew poorly and developed a typical chick blacktongue. The occurrence of these symptoms was prevented by the addition of nicotinic acid to the ration. This paper presents further studies on this deficiency and gives data on the activity of several nicotinic acid esters, as well as studies o...

Mental Symptoms in Pellagra and Nicotinic Acid Deficiency

Experience with Nicotinic Acid

Nicotinic Acid Metabolism

Previous reports from this laboratory have described the isolation of 6-hydroxynicotinic acid and 6-0x0-1 ,4,5,6-tetrahydronicotinic acid from the reaction media of a clostridial species grown on nicotinic acid (1). Bn enzyme that catalyzes the reversible oxidation of nicotinic acid to HNA’ has been purified from extracts of this microorganism (2). Since fortified crude extract of this Clostrid...